Simvastatin

Pharmacology: Simvastatin is a drug that lowers cholesterol levels, which is derived by synthesis as a fermentation product of Aspergillus terreus. The in-vivo simvastatin would hydrolyzed into active metabolites. Mechanism of action of the active metabolite is inhibiting 3-hydroxy-3-metilglutaril coenzyme A reductase (HMG Co-A reductase). Where these enzymes catalyze changes in HMG Co-A into mevalonat acid which is the initial step of cholesterol biosynthesis.


Indications: Treatment with substances that affect the fat content, can be considered its use in individuals at risk of atherosclerosis caused by hiperkolesterolmia. Premises Therapeutic substances that affect levels of saturated fat and cholesterol, when response to diet and other pharmacological treatments are inadequate.

coronary heart disease and hiperkolesterolmia, simvastatin at indicated for:

1. Reduce the risk of coronary heart disease mortality by reducing deaths from coronary disease.

2. Reduce the risk of non-fatal myocardial infarction.

3. Reduce the risk in patients undergoing myocardial revascularization



Hiperkolesterolmia: Simvastatin is indicated to reduce total and LDL cholesterol levels in patients with primary hiperkolesterolmia (type IIa and IIb).
 
Contraindications: - Hypersensitivity to simvastatin or components of this drug. Active liver disease or elevated serum transaminase who settled unclear cause. Pregnant woman breastfeeding.
 
Side Effects: - Abdominal pain, constipation, asthenia, headache, myopathy, rabdomiolisis. in certain cases occur angioneurotik edema. Hypersensitivity reactions such as Anaphylaxis, angiodema, thrombocytopenia, leukopenia, hemolytic anemia.